APOL1 Long-term Kidney Transplantation Outcomes Network Scientific and Data Research Center (APOLLO SDRC) (Collaborative U01)

Funding Opportunity RFA-DK-16-024 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites cooperative agreement applications to establish a multi-disciplinary group of investigators to be known as the APOL1 Long-term Kidney Transplantation Outcomes Research Network (APOLLO) Scientific Data Research Center (SDRC), and runs in parallel with a separate FOA that invites applications for the APOLLO Clinical Centers (CCs) (RFA-DK-16-025). The APOLLO Network consortium will design and conduct studies of a comprehensive, prospective longitudinal cohort to determine the impact of APOL1 genetic variants as susceptibility factors in US kidney transplant recipients who received kidneys from African-American donors. In addition, the consortium will follow the course of African-American kidney donors. Primary outcomes are the rate of change of kidney function in recipients, and rates of acute rejection of the kidney transplant, graft failure, and return to maintenance dialysis rates in the recipients. Outcomes in donors, including vital and renal functional status, will be assessed to the greatest extent possible.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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We report a series of 5 solid organ transplantation recipients diagnosed with STEC-HUS between January 2017 and March 2019 in 2 French nephrology centers (Table 1). One patient had 2 episodes of STEC-HUS. All had severe acute kidney injury (requiring hemodialysis in 2). Neurological involvement was noted during 5 episodes: seizures (n = 4) and confusion/coma (n = 4).
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Letter to the Editor Source Type: research
Abstract Chronic kidney disease (CKD) is characterized by gradually loss of renal mass and functions. It has become a global health problem with hundreds of millions people affected. Both its incidence and prevalence are increasing over time. More than $20,000 are spent on each patients per year. The economic burden on the patients as well as the society is heavy. And their life quality becomes worsen over time. However, there are still limited effective therapeutic strategies on CKD. Patients mainly rely on dialysis and renal transplantation, which cannot prevent all the complications of CKD. Great efforts are ne...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Abstract Renal transplant recipients (RTRs) and non-dialysis chronic kidney disease (ND-CKD) patients display elevated circulating microparticle (MP) counts, whilst RTRs display immunosuppression-induced infection susceptibility. The impact of aerobic exercise on circulating immune cells and microparticles is unknown in RTRs. Fifteen RTRs (age 52.8±14.5 years, estimated glomerular filtration rate [eGFR] 51.7±19.8 ml/min/1.73m2 [mean ± SD]), 16 ND-CKD patients (54. ± 6.3 years, eGFR 61.9±21.0 ml/min/1.73m2, acting as a uremic control group), and 16 HCs (52.2±16.2 years, eGF...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
Kidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
We examined the role of iron deficiency and inflammation in RLS in pediatric CKD.Methods:This cross-sectional study examined RLS prevalence in three groups of pediatric patients with CKD: nontransplant, nondialysis CKD (estimated GFR
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Donate Life America is now in partnership with a large dialysis corporation to expand living donor resources for waiting recipients on the kidney transplant list.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Nephrology News Source Type: news
We report a high vertebral fracture prevalence and incidence in transplantation-eligible patients on dialysis, suggesting that these patients may benefit from radiographic screening for vertebral fractures. Parathyroid hormone had a U-shaped association with vertebral fracture risk.IntroductionVertebral fractures are often overlooked, but even undiagnosed vertebral fractures negatively impact physical functioning, quality of life, and mortality. The risk of vertebral fractures in end-stage renal disease (ESRD) patients is unclear, and parathyroid hormone (PTH) might play a role in the development of vertebral fractures. We...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
This article explains the motivation for ambulatory hemodialysis and provides an overview of the necessary features of key technologies that will be the basis for new wearable and implantable devices. Early work by pioneers of hemodialysis is described followed by recent experience using a wearable unit on patients. Finally, ongoing efforts to develop an implantable device for kidney replacement and its potential for implantable hemodialysis are presented. PMID: 31727617 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
Surgeons at the Cleveland Clinic managed to implant a donor kidney into a patient using a surgical robot, and all through one small incision. The technique, in which instruments as well as the donor kidney can be passed through a four centimeter (1.6...
Source: Medgadget - Category: Medical Devices Authors: Tags: Surgery Urology Source Type: blogs
ConclusionsMarked differences in risk for ESKD across types of donor-recipient relationship were observed for Asian, black, and white donors. These findings warrant further validation with more robust data to better inform clinical practice guidelines.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
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