Cocaine promotes primary human astrocyte proliferation via JNK-dependent up-regulation of cyclin A2.

CONCLUSION: Cocaine-induced abnormal increases in the number of astrocytes may cause disruption in neuron-glia signaling and contribute to synaptic impairment in the CNS. Understanding the mechanisms of cocaine's effects on human astrocytes may help to reveal the involvement of glial cells in addictive behaviors. PMID: 27834787 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research

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Authors: Malik E, Adelson M, Sason A, Schreiber S, Peles E Abstract Objective: Comorbidity of depression among individuals with opioid addiction is highly prevalent, but their outcome in methadone maintenance treatment (MMT) is not well determined. Methods: Characteristics and outcomes (retention until December 2017) of newly admitted and already (5.5 ± 4 years) in MMT patients with available Hamilton Depression Rating Scale (HAM-D) scores on admission were studied. Results: During psychiatric intake on admission, 70 (21.2%) of 330 patients were diagnosed with high depressive symptoms beyond th...
Source: Journal of Dual Diagnosis - Category: Addiction Tags: J Dual Diagn Source Type: research
Three medications to help fight opioid addiction are widely underused in treatment of people with opioid use disorder, according to a new study.
Source: Health News - - Category: Consumer Health News Source Type: news
Conclusion: The version of the ASI-6 adapted to the Colombian context was found to have good reliability and validity, thus it can be introduced into clinical practice. However, additional studies are needed to evaluate its responsiveness and structural validity. PMID: 31529824 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
Authors: Prawiroharjo P, Ellydar H, Pratama P, Edison RE, Suaidy SEI, Amani NZ, Carissima D Abstract We aimed to find the differences in memory capabilities between pornography-addicted and nonaddicted juveniles. We enrolled 30 juveniles (12-16 y) consisting of 15 pornography addiction and 15 nonaddiction subjects. We used Rey Auditory Verbal Learning Test (RAVLT) to measure verbal memory, Rey-Osterrieth Complex Figure Test (ROCFT) for visual memory, along with Trail Making Test A and B (TMT-A and TMT-B) for attention. We found a significant reduction in the RAVLT A6 result of the addiction group (nonaddicti...
Source: Neurology Research International - Category: Neurology Tags: Neurol Res Int Source Type: research
Conclusions/Importance: Perceptions of prescription drug abuse among primary care and addiction medicine patients in Appalachia are multifaceted, especially regarding prescription drug acquisition and distribution. Clinical practice implications for mitigating prescription drug abuse are discussed. PMID: 31526177 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
BOSTON (CBS) – A Newburyport mother says her son’s vaping addiction got so bad, he was diagnosed with a restrictive lung condition. Cade Beauparlant was the captain of the Newburyport hockey team, until he was benched in his senior year once he was caught smoking his Juul, a popular electronic cigarette, in school. “He’d be skating and he wouldn’t even be able to skate a full shift for the hockey team without having to come off because he was so short of breath,” his mom explained. After Cade got in trouble, his parents brought him to Mass General, where they discovered he had developed ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Watch Listen JUUL Kristina Rex Newburyport News vaping Source Type: news
This study investigated the effects of free morphine and morphine encapsulated in unilamellar and multilamellar liposomes on antinociception and on the expression and extinction of the positive and negative memories associated with environmental cues. The hot plate test was used to measure central pain. The rewarding effects of morphine were analyzed by the conditioned-place preference (CPP) test, and the aversive aspects of naloxone-precipitated morphine withdrawal were evaluated by the conditioned-place aversion (CPA) paradigm. Our results show that encapsulated morphine yields prolonged antinociceptive effects compared ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Health officials have recommended that people refrain from using e-cigarettes as they investigate a severe lung illness that has killed eight people. Here are some things to consider.
Source: NYT Health - Category: Consumer Health News Authors: Tags: E-Cigarettes Smoking and Tobacco Nicotine Teenagers and Adolescence Addiction (Psychology) Deaths (Fatalities) Source Type: news
Abstract PURPOSE: Gender inequality and sexism are often at the root of domestic violence against women and children, with both serving to justify male domination. This runs in parallel with mother-blaming bias, which constitutes a pervasive common sense and scientific error derived from the myth of the good and the bad mother, characterising a large part of studies on deviance. The purpose of this paper is to consider the possible role of sexism in prisoners' deviant biographies; for this, the authors considered the role of the mother in the biographies of prisoners, and the results lend support to the idea that ...
Source: International Journal of Prisoner Health - Category: Criminology Authors: Tags: Int J Prison Health Source Type: research
Abstract PURPOSE: Most research on posttraumatic stress disorder (PTSD) and offending has been conducted with special populations (e.g. veterans and female inmates) and generally overlooks the additive effect of panic disorder (PD) in offending patterns. The purpose of this paper is to assess the prevalence of PTSD and PD among jail inmates, while simultaneously examining the relationships between these disorders, offending types and frequency. DESIGN/METHODOLOGY/APPROACH: A random sample of adults recently booked into a local county jail participated in the Comprehensive Addictions and Psychological Evaluati...
Source: International Journal of Prisoner Health - Category: Criminology Authors: Tags: Int J Prison Health Source Type: research
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