Neurocognitive function varies by IDH1 genetic mutation status in patients with malignant glioma prior to surgical resection

Conclusion. Patients with IDH1-WT show reduced NCF compared with those with IDH1-M malignant gliomas. Lesion volume is inversely associated with NCF for patients with IDH1-WT, but not IDH1-M tumors. These findings are consistent with the hypothesis that patients with IDH1-WT tumors present with more severe NCF impairment due to greater lesion momentum, which may impede compensatory neuroplasticity and cerebral reorganization.
Source: Neuro-Oncology - Category: Cancer & Oncology Authors: Tags: Clinical Investigations Source Type: research