Long-term Outcomes of Parkinson's Disease Patients with Normal Cognition. (P5.260)

Conclusion:More than one-third of PD patients with NC develop cognitive impairment within 4 years, and the majority of new MCI cases convert to dementia within 3 years. Worse executive, language and memory abilities all predict future decline. These results are consistent with previous studies reporting that the overwhelming majority of PD patients develop cognitive impairment long-term, and have implications for understanding disease course and clinical care.Disclosure: Dr. Pigott has nothing to disclose. Dr. Rick has nothing to disclose. Dr. Hurtig has nothing to disclose. Dr. Chen-Plotkin has received research support from Pfizer Inc. Dr. Duda has received personal compensation for activities with Teva Neuroscience. Dr. Duda holds stock and/or stock options in Celgene Corporation. Dr. Morley has nothing to disclose. Dr. Dahodwala has received research support from Teva Neuroscience. Dr. Akhtar has nothing to disclose. Dr. Siderowf has received personal compensation for activities with Avid Radiopharmaceuticals. Dr. Siderowf has received research support from the National Institute of Neurological Disorders and Stroke. Dr. Goldmann Gross has nothing to disclose. Dr. Xie has nothing to disclose. Dr. Trojanowksi has received personal compensation for activities with Pfizer Inc., Johnson & Johnson, MetLife, and Bristol-Myers Squibb Co. as a consultant. Dr. Trojanowski has received royalty payments through Penn licenses. Dr. Trojanowksi has received research support from As...

Source: Neurology - April 9, 2014 Category: Neurology Authors: Pigott, K., Rick, J., Hurtig, H., Chen-Plotkin, A., Duda, J., Morley, J., Chahine, L., Dahodwala, N., Fleisher, J., Akhtar, R., Siderowf, A., Goldmann Gross, R., Xie, S., Trojanowski, J., Weintraub, D. Tags: Movement Disorders: Cognition and Parkinson ' s Disease Source Type: research