Downregulation of Forkhead box F1 gene expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia

ConclusionOur study demonstrates a strikingly reduced expression of FoxF1 in the pulmonary vasculature of nitrofen-induced CDH. Altered FoxF1 gene expression during embryogenesis may participate in vascular maldevelopment resulting in PH in this animal model.

http://link.springer.com/10.1007/s00383-016-3967-1

Source: Pediatric Surgery International - September 22, 2016 Category: Surgery Source Type: research