Simvastatin's effects on survival and outcome in traumatic braininjury patients: a comparative study - Naghibi T, Madani S, Mazloomzadeh S, Dobakhti F.

BACKGROUND/AIM: Mortality and morbidity still remain high in patients with traumatic brain injuries. Understanding the role of new treatments in these patients is critical. The aim of this study was to determine the effect of simvastatin on survival and ou...
Source: SafetyLit - Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

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In this study, mature DCs (mDCs), generated from the GM-CSF and IL-4 induced bone marrow cells, were intravenously injected into wild-type mice. Three days later, assays showed that the mDCs were indeed able to return to the thymus. Homing DCs have been mainly reported to deplete thymocytes and induce tolerance. However, medullary TECs (mTECs) play a crucial role in inducing immune tolerance. Thus, we evaluated whether the mDCs homing into the thymus led to TECs depletion. We cocultured mDCs with mTEC1 cells and found that the mDCs induced the apoptosis and inhibited the proliferation of mTEC1 cells. These effects were onl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
STATINS lower harmful cholesterol levels but they can interact with other lifestyle decisions. It is generally safe to drink alcohol on statins, but there is a key caveat.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Traumatic brain injury (TBI), also known as the "Silent Epidemic," is a growing devastating global health problem estimated to affect millions of individuals yearly worldwide with little public recognition, leading to many individuals living with a TBI-rel...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Chest. 2021 Aug;160(2):e225-e231. doi: 10.1016/j.chest.2021.03.040.ABSTRACTA 60-year-old man with no significant medical history presented to the pulmonology clinic with 2 years of progressive weakness and shortness of breath. Showering and other activities of daily living caused him significant fatigue and dyspnea. He had a 20-pack-year smoking history, but no significant history of alcohol or illicit drug use. He did not take any prescribed or over-the-counter medications for chronic medical conditions and had never been on statin therapy. Vital signs were significant for an oxygen saturation of 91% on 4-L nasal cannula....
Source: Chest - Category: Respiratory Medicine Authors: Source Type: research
Curr Pharm Des. 2021 Aug 3. doi: 10.2174/1381612827666210804095300. Online ahead of print.ABSTRACTVariants in the ryanodine receptor-1 gene (RYR1) have been associated with a wide range of neuromuscular conditions, including various congenital myopathies and malignant hyperthermia (MH). More recently, a number of RYR1 variants, mostly MH-associated, have been demonstrated to contribute to rhabdomyolysis events not directly related to anesthesia in otherwise healthy individuals. This review focuses on RYR1-related rhabdomyolysis, in the context of several clinical presentations (i.e., exertional rhabdomyolysis, exertional h...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSION: Shared and different risk factors for PsA, psoriasis, RA, and AS were identified. Statin use was inversely associated with all 4 conditions.PMID:34334358 | DOI:10.3899/jrheum.210006
Source: Journal of Rheumatology - Category: Rheumatology Authors: Source Type: research
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