Molecular pathways driving disease-specific alterations of intestinal epithelial cells.

Molecular pathways driving disease-specific alterations of intestinal epithelial cells.
Cell Mol Life Sci. 2016 Sep 13;
Authors: López-Posadas R, Neurath MF, Atreya I
Abstract
Due to the fact that chronic inflammation as well as tumorigenesis in the gut is crucially impacted by the fate of intestinal epithelial cells, our article provides a comprehensive overview of the composition, function, regulation and homeostasis of the gut epithelium. In particular, we focus on those aspects which were found to be altered in the context of inflammatory bowel diseases or colorectal cancer and also discuss potential molecular targets for a disease-specific therapeutic intervention.
PMID: 27624395 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - September 12, 2016 Category: Cytology Authors: López-Posadas R, Neurath MF, Atreya I Tags: Cell Mol Life Sci Source Type: research