OX40 Regulates pressure overload induced cardiac hypertrophy and remodelling Via CD4+ T Cells

In this study, we observed a noticeable increase in OX40 expression during cardiac remodelling in rodent heart. In this study, cardiac hypertrophy was induced by aortic banding in OX40 knockout (KO) mice and wild-type mice. After 8 weeks, the OX40 KO mice showed significantly attenuated cardiac hypertrophy, fibrosis, and inflammation as well as preserved cardiac function compared with the wild-type mice. Follow-up in vitro studies suggested that CD4+ T lymphocyte proliferation and pro-inflammatory cytokine release were significantly decreased, while anti-inflammatory cytokine release was considerably increased in OX40 KO mice compared with wild-type mice as assessed by CCK-8 assay and ELISA. Co-culturing neonatal rat cardiomyocytes with the activated supernatant of CD4+ T lymphocytes from OX40 KO mice reduced the hypertrophy response. Interestingly, OX40 KO mice with reconstituted CD4+T lymphocytes presented deteriorated cardiac remodelling. Collectively, our data indicate that OX40 regulates cardiac remodelling via the modulation of CD4+ T lymphocytes.

Source: Clinical Science - August 30, 2016 Category: Biomedical Science Authors: Wu, Q. Q., Yuan, Y., Jiang, X. H., Xiao, Y., Yang, Z., Ma, Z. G., Liao, H. H., Liu, Y., Chang, W., Bian, Z. Y., Tang, Q. Z. Tags: PublishAheadOfPrint Source Type: research