Characterisation of liver pathogenesis, human immune responses and drug testing in a humanised mouse model of HCV infection

Conclusions
The HIL mouse provides a model for the understanding of HCV-specific human immune responses and HCV-associated disease pathologies. It could also serve as a platform for antifibrosis and immune-modulatory drug testing.

Source: Gut - September 7, 2016 Category: Gastroenterology Authors: Keng, C. T., Sze, C. W., Zheng, D., Zheng, Z., Yong, K. S. M., Tan, S. Q., Ong, J. J. Y., Tan, S. Y., Loh, E., Upadya, M. H., Kuick, C. H., Hotta, H., Lim, S. G., Tan, T. C., Chang, K. T. E., Hong, W., Chen, J., Tan, Y.-J., Chen, Q. Tags: Cirrhosis, Open access, Hepatic cancer Hepatology Source Type: research