Case Series With Histopathologic and Radiographic Analyses Following Failure of Fresh Osteochondral Allografts of the Talus

Conclusion:
A histopathologic analysis of 8 retrieved, failed talar allografts was performed. Graft failure appeared to be primarily biologic, with an extensive loss of viable cartilaginous and osseous tissue at the graft-host interface. This study provides the first evidence of a potential CD4+ and CD8+ lymphocyte-mediated failure mechanism in fresh osteochondral allografts that were revised following collapse.

Level of Evidence:
Level IV, case series.

Source: Foot and Ankle International - September 5, 2016 Category: Orthopaedics Authors: Pomajzl, R. J., Baker, E. A., Baker, K. C., Fleischer, M. M., Salisbury, M. R., Phillips, D. M., Fortin, P. T. Tags: Articles Source Type: research