Antimicrobial susceptibility and molecular epidemiology of multidrug-resistant Klebsiella pneumoniae in Central China.

This study investigated the epidemiology and resistance profiles of K. pneumoniae strains isolated in Central China between 2009 and 2014. Antimicrobial susceptibility tests and polymerase chain reaction were used to investigate the prevalence and resistance of ESBLs and carbapenemases produced by K. pneumoniae, and the prevalence of KPC-producing K. pneumoniae was investigated by multilocus sequence typing. Carbapenem resistance has emerged as the main concern in K. pneumoniae infections, with phenotype tests detecting carbapenemases in nearly 20% of isolates. KPC-producing isolates were clonally related in a local epidemic, with ST11 being the reservoir for the blaKPC-2 gene and ESBL genes. The prevalence of ESBL enzymes was dynamic during the 6-year period, and blaCTX-M-55 might become prevalent in the future. Our findings demonstrate the high prevalence of carbapenemase- and ESBL-producing K. pneumoniae in Central China and predict a local epidemic of KPC-2 and CTX-M-55 in the future. PMID: 27580572 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research