More parents believe vaccines are ‘ unnecessary, ’ while a mumps outbreak grows
The contrast between parents’ attitudes about vaccines today and a decade ago is striking. A survey published Monday by the American Academy of Pediatrics shows that more and more moms and dads are refusing the shots for their children. Much of the blame for this phenomenon can be attributed to continuing claims from everyone from actor Jim Carrey to […]Related:Singapore Zika cases rise to 56 at one construction site; Malaysia starts border screeningPrenatal depression may be the most severe form of maternal depressionCPAP machines don’t prevent heart attacks, strokes in some sleep apnea sufferers
ConclusionsSubcutaneous immunotherapy with depigmented‐polymerized allergen extracts is a safe and clinically effective treatment for LAR to Phleum pratense.clinicaltrials. gov identifier: NCT02126111.This article is protected by copyright. All rights reserved.
ConclusionMarijuana use appears to be associated with subclinical atherosclerosis, but only among ever tobacco users.
Authors: Braukhaus C, Jahnke U, Zimmermann T Abstract A Parkinson's disease is attended by high strain for the patients and an obvious loss of relationship functioning. Partners of patients (N=110) were evaluated via self-assessment in terms of own depression (PHQ-9), own fear of progression (PA-F-P-KF), relationship quality (PFB) as well as perceived deficits in everyday life and nonverbal communication. 26% of women and 11% of men showed depression scores, 51% of women and 41% of men dysfunctional fear of progression and about 60% were unsatisfied with their relationship. Gender-specific differences regarding the...
Frank Euteneuer, Katharina Dannehl, Adriana del Rey, Harald Engler, Manfred Schedlowski, Winfried Rief
For a depressed patient, a single day without symptom improvement means yet another day of suffering. The currently available antidepressants require weeks or months to achieve appreciable symptom remission and remain ineffective in a large number of patients. Severely depressed patients are at high risk of suicide, making delayed symptom improvement a life-threatening unresolved problem in psychiatry. Therefore, there is an urgent need to develop new strategies to treat depression more rapidly and more effectively to achieve fast and sustained symptom relief.
A number of placebo-controlled trials have provided evidence of rapid and sustained antidepressant actions after the administration of a single, subanesthetic dose of the noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine in treatment-refractory depressed patients. Ketamine is a racemic mixture comprised of the (S)- and (R)-ketamine enantiomers, with (S)-ketamine being approximately fourfold more potent at inhibiting the NMDAR. Similar to racemic ketamine, clinical studies in depressed patients have indicated that a 40-minute intravenous infusion of (S)-ketamine exerts rapid antidepressant actions (1).
A range of evidence points to increased inflammation in stress-related and mood disorders (1,2). Relevant data have emerged from both animal models and clinical research (3) and include work on alterations in inflammatory markers and responses of such biomarkers to treatments with anti-inflammatory agents and other psychiatric interventions (4,5). Indeed, exciting advances in psychoneuroimmunology have raised hopes of improving the diagnosis and treatment of stress-related and mood disorders.
In this issue of Biological Psychiatry, Scifo et al. (1) follow a reasonable clinical and epidemiologic classification to separate biological traits and states. They base their hypothesis on existing strong findings that patients often have lifelong recurring episodes of major depression of increasing severity, shorter remission periods, and red uced therapeutic response. Based on these observations, they reason that patients with differing clinical courses (single episodes, single episodes in remission, recurrent episodes, recurrent episodes in remission, and control subjects) should show differing biological traits and states.
Authors: Heffner JL, Mull KE, McClure JB, Bricker JB Abstract BACKGROUND: Prior studies have suggested that, among the domains of depressive symptoms, low positive affect (PA) may have a distinct relationship with smoking cessation and relapse. However, the empirical basis for PA-focused interventions cessation is limited, with some mixed findings. OBJECTIVES: Using a large, diverse sample of treatment-seeking smokers, this study tested the hypothesis that PA adds unique predictive value beyond the effects of the other symptom domains in models of cessation and relapse. METHODS: Adult smokers participating ...
Global health officials stepped up defensive measures against Zika over the weekend as the virus continued to expand its reach at a rapid pace. Singapore reported one of the largest single clusters outside of the Americas, confirming 56 infections, mostly among foreign workers at a construction site. On Monday, inspectors armed with insecticide were visiting high-rise public housing […]Related:More parents believe vaccines are ‘unnecessary,’ while a mumps outbreak growsPrenatal depression may be the most severe form of maternal depressionCPAP machines don’t prevent heart attacks, str...