In vitro Ceftaroline Combinations against Methicillin-resistant Staphylococcus aureus.

In vitro Ceftaroline Combinations against Methicillin-resistant Staphylococcus aureus.
J Med Microbiol. 2016 Aug 22;
Authors: García AB, Candel FJ, López L, Chiarella F, Viñuela-Prieto JM
Abstract
We studied in vitro ceftaroline combinations against 61 methicillin-resistant Staphylococcus aureus (MRSA) isolates, 18 of them also resistant to linezolid, using overlapping E-test method. Daptomycin-Ceftaroline combination obtained lower Fractional Inhibitory Concentration (FIC) values, in comparison with those including vancomycin or linezolid against MRSA (p<0.05). All methicillin and linezolid resistant Staphylococcus aureus (MLRSA) strains were resistant to ceftaroline, nevertheless, combinations with vancomycin or daptomycin showed higher synergy or addtion rates than those with linezolid.
PMID: 27553740 [PubMed - as supplied by publisher]

Source: Journal of Medical Microbiology - August 21, 2016 Category: Microbiology Authors: García AB, Candel FJ, López L, Chiarella F, Viñuela-Prieto JM Tags: J Med Microbiol Source Type: research