Neuro-Endocrine Effects of Aqueous Extract of Amaranthus viridis (Linn.) Leaf in Male Wistar Rat Model of Cyclophosphamide-Induced Reproductive Toxicity

Publication date: Available online 3 August 2016 Source:Toxicology Reports Author(s): Ayoka Oladele Abiodun, Ojo Opeyemi Esther, Imafidon Eseigbe Christian, Ademoye Kehinde Aderonke, Oladele Abraham Ayowole Cyclophosphamide (CP) is a widely used cytotoxic alkylating agent with antitumor and immunosuppressant properties that is associated with various forms of reproductive toxicity. The significance of natural antioxidants of plant origin should be explored, especially in a world with increasing incidence of patients in need of chemotherapy. The neuro-endocrine effects of aqueous extract of Amaranthus viridis (Linn.) leaf (AEAVL) in Wistar rats with CP-induced reproductive toxicity was determined. Forty rats were used for this study such that graded doses of the extract were administered following CP-induced reproductive toxicity and comparisons were made against control, toxic and standard (vitamin E) groups at p<0.05. The synthetic drugs (CP, 65mg/kg i.p. for 5 days; Vitamin E, 100mg/kg p.o. for 30 days) as well as the extract (100, 200 and 400mg/kg p.o. for 30 days) were administered to the rats at 0.2mL/100g. CP induced reproductive toxicity as evidenced by significantly lowered levels of FSH, LH and testosterone, perturbation of sperm characterization, deleterious disruptions of the antioxidant system as evidenced by decreased levels of GSH as well as elevation of TBARS activity. Histopathological examination showed hemorrhagic lesions with scanty and hypert...
Source: Toxicology Reports - Category: Toxicology Source Type: research