Neurotoxicity of Ammonia.

Neurotoxicity of Ammonia. Neurochem Res. 2016 Jul 28; Authors: Oja SS, Saransaari P, Korpi ER Abstract Abnormal liver function has dramatic effects on brain functions. Hyperammonemia interferes profoundly with brain metabolism, astrocyte volume regulation, and in particular mitochondrial functions. Gene expression in the brain and excitatory and inhibitory neurotransmission circuits are also affected. Experiments with a number of pertinent animal models have revealed several potential mechanisms which could underlie the pathological phenomena occurring in hepatic encephalopathy. PMID: 27465396 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27465396?dopt=Abstract

Source: Neurochemical Research - July 27, 2016 Category: Neuroscience Authors: Oja SS, Saransaari P, Korpi ER Tags: Neurochem Res Source Type: research