Multiplex PCR assay underreports true bloodstream infections with coagulase-negative staphylococci in hematological patients with febrile neutropenia

SeptiFast multiplex PCR assay was evaluated for detecting true bloodstream infections (BSIs) with coagulase-negative staphylococci (CoNS) in neutropenic hematological patients. Sensitivity for samples representing true CoNS-BSIs was 23.3% with an integrated cutoff and increased to 83.3% if the cutoff was neglected. Hence, the cutoff may prohibit timely targeted antimicrobial therapy.

Source: Diagnostic Microbiology and Infectious Disease - May 5, 2016 Category: Microbiology Authors: Yvonne Reers, Evgeny A. Idelevich, Hanna P ätkau, Maria Cristina Sauerland, Sascha Tafelski, Irit Nachtigall, Wolfgang E. Berdel, Georg Peters, Gerda Silling, Karsten Becker, Molecular Diagnostics of Sepsis Study Group Tags: Bacteriology Source Type: research