The role of ADAMTS13 in acute myocardial infarction: cause or consequence?

Conclusions
No correlation was found between VWF/ADAMTS13 and infarct size in patients. However, patients suffering from IMH had significantly higher VWF activity and lower ADAMTS13 activity. Intracoronary administration of rADAMTS13 did not decrease infarct size or IMH in a porcine model of myocardial ischaemia-reperfusion. These data dispute the imbalance in ADAMTS13 and VWF as the cause of no reflow.

Source: Cardiovascular Research - July 21, 2016 Category: Cardiology Authors: Eerenberg, E. S., Teunissen, P. F. A., van den Born, B.-J., Meijers, J. C. M., Hollander, M. R., Jansen, M., Tijssen, R., Beliën, J. A. M., van de Ven, P. M., Aly, M. F., Kamp, O., Niessen, H. W., Kamphuisen, P. W., Levi, M., van Royen, N. Tags: Cardiac biology and remodelling Source Type: research