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Chlamydia vaccine research 'shows early progress'

Conclusion It's easy to get carried away by headlines about vaccines for common and damaging diseases, but early-stage studies in mice don't always translate into usable vaccines for humans. People have been trying to find an effective vaccine against chlamydia since the bacteria was discovered in 1957, and research is still being carried out into several different vaccine candidates. This vaccine may turn out to be effective, but it could become one of the many failed vaccine candidates seen over the years. This is a small study in just 20 specially bred laboratory mice, and involved a type of chlamydia (Chlamydia muridarum) only mice get. Much more work will be needed to see whether this experiment can be successfully repeated, and whether the vaccine is safe for use in humans, before we can even look at whether it is effective in preventing Chlamydia trachomatis in humans. Read more about chlamydia prevention and sexual health. Links To The Headlines Could a NOSE SPRAY prevent chlamydia? World's first vaccine for the STD 'is showing promising results'. Mail Online, July 19 2016 Chlamydia vaccine 'shows promise'. BBC News, July 20 2016 Links To Science Bulira DC, Steven Lianga, S, Leec A, et al. Immunization with chlamydial type III secretion antigens reduces vaginal shedding and prevents fallopian tube pathology following live C. muridarum challenge. Published online June 17 2016
Source: NHS News Feed - Category: Consumer Health News Tags: Lifestyle/exercise Medication Medical practice Source Type: news

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The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia is also the leading cause of preventable blindness in the world. Despite increased surveillance, prevalence continues to increase, and the need to develop an effective chlamydial vaccine remains.Technologies: 1. A plasmid-deficient Chlamydia trachomatis strain which was s...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
Publication date: Available online 2 March 2018 Source:Microbes and Infection Author(s): Saskia Lehr, Juliane Vier, Georg Häcker, Susanne Kirschnek The obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial agent of sexually transmitted disease world-wide. Chlamydia trachomatis primarily infects epithelial cells of the genital tract but the infection may be associated with ascending infection. Infection-associated inflammation can cause tissue damage resulting in female infertility and ectopic pregnancy. The precise mechanism of inflammatory tissue damage is unclear but earlier studies im...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Conclusion: Our results suggest that infection with U. urealyticum alone and any of the five sexually transmitted infections are likely to affect sperm morphology and semen volume, respectively. PMID: 29376018 [PubMed]
Source: Clinical and Experimental Reproductive Medicine - Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research
(University of Texas Health Science Center at San Antonio) Exposing the gut to chlamydia protects against subsequent infection in the genital tract and other tissues, researchers from UT Health San Antonio discovered. Chlamydia is the nation's most common sexually transmitted disease and causes infertility, ectopic pregnancy and pelvic inflammatory disease if left untreated.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Abstract Human papillomavirus (HPV) persistent infection is the necessary but not sufficient cause of cervical cancer. Other co-factors are required to induce cell transformation that will evolve to malignant cervical cancer. These co-factors include physical elements, other sexually transmitted infections, and immune response. Chlamydia trachomatis the most common bacterial sexually transmitted infection is often asymptomatic but causes various syndromes such as cervicitis, endometritis, pelvic inflammatory disease, and infertility. It is established that this bacterium is involved in cell proliferation process a...
Source: Current Microbiology - Category: Microbiology Authors: Tags: Curr Microbiol Source Type: research
Chlamydia trachomatis is one of the most common sexually transmitted infections globally; WHO estimates that there are more than 130 million new cases of chlamydia annually. Because chlamydial infections are often asymptomatic, screening programmes are imperative to control infection and to prevent adverse sequelae. Chlamydial infections are important causes of pelvic inflammatory disease and tubal infertility and can lead to ectopic pregnancies.1 Additionally, chlamydial infections increase the risk of acquiring HIV infection.
Source: The Lancet Infectious Diseases - Category: Infectious Diseases Authors: Tags: Comment Source Type: research
(Natural News) Scientists are being asked to take into consideration a new aspect when it comes to acquiring sexually transmitted diseases (STD), mainly in part because there are now forms of STD that can be transmitted even through oral and anal sex. “Does active oral sex contribute to female infertility?” This is the question asked...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Authors: Di Pietro M, Filardo S, Porpora MG, Recine N, Latino MA, Sessa R Abstract HPV and Chlamydia trachomatis are the most common causes of sexually transmitted diseases worldwide. Most infections are asymptomatic and left untreated lead to severe reproductive tract sequelae such as cervical cancer and infertility. Interestingly, C. trachomatis may also increase the susceptibility to HPV infection as well as contribute to viral persistence. Recently, a growing body of evidence has suggested that the composition of the cervico-vaginal microbiota plays a key role in the susceptibility and outcome of genital infect...
Source: New Microbiologica - Category: Microbiology Tags: New Microbiol Source Type: research
Abstract Chlamydia trachomatis, a leading bacterial cause of sexually transmitted infection-induced infertility, is frequently detected in the gastrointestinal tract. Chlamydia muridarum, a model pathogen for investigating C. trachomatis pathogenesis, readily spreads from the mouse genital tract to the gastrointestinal tract, establishing long-lasting colonization. C. muridarum mutants, despite their ability to activate acute oviduct inflammation, are attenuated in inducing tubal fibrosis and are no longer able to colonize the gastrointestinal tract, suggesting that the spread of C. muridarum to the gastrointestin...
Source: Trends in Microbiology - Category: Microbiology Authors: Tags: Trends Microbiol Source Type: research
Conclusions: Our experiments demonstrated that CPAF selectively and specifically degrades chlamydial T cell antigens, which chlamydia may utilize as a novel mechanism for evading host immune responses to promote chlamydia survival.
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
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