Chlamydia vaccine research 'shows early progress'

Conclusion It's easy to get carried away by headlines about vaccines for common and damaging diseases, but early-stage studies in mice don't always translate into usable vaccines for humans. People have been trying to find an effective vaccine against chlamydia since the bacteria was discovered in 1957, and research is still being carried out into several different vaccine candidates. This vaccine may turn out to be effective, but it could become one of the many failed vaccine candidates seen over the years. This is a small study in just 20 specially bred laboratory mice, and involved a type of chlamydia (Chlamydia muridarum) only mice get. Much more work will be needed to see whether this experiment can be successfully repeated, and whether the vaccine is safe for use in humans, before we can even look at whether it is effective in preventing Chlamydia trachomatis in humans. Read more about chlamydia prevention and sexual health. Links To The Headlines Could a NOSE SPRAY prevent chlamydia? World's first vaccine for the STD 'is showing promising results'. Mail Online, July 19 2016 Chlamydia vaccine 'shows promise'. BBC News, July 20 2016 Links To Science Bulira DC, Steven Lianga, S, Leec A, et al. Immunization with chlamydial type III secretion antigens reduces vaginal shedding and prevents fallopian tube pathology following live C. muridarum challenge. Published online June 17 2016
Source: NHS News Feed - Category: Consumer Health News Tags: Lifestyle/exercise Medication Medical practice Source Type: news

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myLAB Box, a healthcare company based in California, has developed and pioneered an at-home sexually transmitted disease (STD) testing service. With the number of STDs rising, the Centers for Disease Control and Prevention estimates that nearly 20 mi...
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Capsid protein Vp1 from chlamydiaphage φCPG1 effectively alleviates cytotoxicity induced by Chlamydia trachomatis. Exp Ther Med. 2018 Oct;16(4):3286-3292 Authors: Ren J, Guo Y, Shao L, Liu Y, Liu Q Abstract Chlamydia trachomatis is the leading cause of sexually transmitted bacterial infections. C. trachomatis genital infection may lead to pelvic inflammatory disease, ectopic pregnancy and tubal infertility, which are major public health problems. However, the pathogenic mechanisms of this bacterium remain unclear, and the efficacy of clinical therapeutics is unsatisfactory. In the current study, wh...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
Recently the Centers for Disease Control and Prevention (CDC) has reported the dramatic increase of sexually transmitted diseases in the U.S.  In fact, for the fourth year in a row the numbers have continued to rise. Among the rise, specific sexually transmitted diseases include: gonorrhea has been diagnosed in 555,608 cases in preliminary 2017 data (an increase of 67%  from 2013) syphilis has been diagnosed in 30,644 cases (an increase of 76% from 2013) chlamydia was reported with more than 1.7 million cases in 2017 These three diseases can be treated with antibiotics but gonorrhea has become antibiotic resist...
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Sexually transmitted disease (STD) rates in the U.S. are at a record high for the fourth year in a row, according to new data from the Centers for Disease Control and Prevention (CDC). All told, nearly 2.3 million cases of chlamydia, gonorrhea and syphilis were diagnosed in the U.S. in 2017. That’s 200,000 more cases than were diagnosed in 2016, a year that also had a record-high number of cases, according to the CDC. “We are now very concerned about this steep and sustained increase that we’re seeing,” says Dr. Gail Bolan, the director of the CDC’s Division of STD Prevention. “We’...
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Publication date: May 2018Source: Microbes and Infection, Volume 20, Issue 5Author(s): Saskia Lehr, Juliane Vier, Georg Häcker, Susanne KirschnekAbstractThe obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial agent of sexually transmitted disease world-wide. Chlamydia trachomatis primarily infects epithelial cells of the genital tract but the infection may be associated with ascending infection. Infection-associated inflammation can cause tissue damage resulting in female infertility and ectopic pregnancy. The precise mechanism of inflammatory tissue damage is unclear but earlier studie...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Chlamydia trachomatis (Ct) constitutes the most prevalent sexually transmitted bacterium worldwide. Chlamydial infections can lead to severe clinical sequelae including pelvic inflammatory disease, ectopic pregnancy, and tubal infertility. As an obligate intracellular pathogen, Ct has evolved multiple strategies to promote adhesion and invasion of host cells, including those involving both...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: PNAS Plus Source Type: research
The National Institute of Allergy and Infectious Diseases has invented three chlamydial vaccine technologies, which have shown promising preclinical efficacy. Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection. If left untreated, chlamydia infection can lead to pelvic inflammatory disease and infertility. Chlamydia is also the leading cause of preventable blindness in the world. Despite increased surveillance, prevalence continues to increase, and the need to develop an effective chlamydial vaccine remains.Technologies: 1. A plasmid-deficient Chlamydia trachomatis strain which was s...
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Publication date: Available online 2 March 2018 Source:Microbes and Infection Author(s): Saskia Lehr, Juliane Vier, Georg Häcker, Susanne Kirschnek The obligate intracellular bacterium Chlamydia trachomatis is the most common bacterial agent of sexually transmitted disease world-wide. Chlamydia trachomatis primarily infects epithelial cells of the genital tract but the infection may be associated with ascending infection. Infection-associated inflammation can cause tissue damage resulting in female infertility and ectopic pregnancy. The precise mechanism of inflammatory tissue damage is unclear but earlier studies im...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Conclusion: Our results suggest that infection with U. urealyticum alone and any of the five sexually transmitted infections are likely to affect sperm morphology and semen volume, respectively. PMID: 29376018 [PubMed]
Source: Clinical and Experimental Reproductive Medicine - Category: Reproduction Medicine Tags: Clin Exp Reprod Med Source Type: research
(University of Texas Health Science Center at San Antonio) Exposing the gut to chlamydia protects against subsequent infection in the genital tract and other tissues, researchers from UT Health San Antonio discovered. Chlamydia is the nation's most common sexually transmitted disease and causes infertility, ectopic pregnancy and pelvic inflammatory disease if left untreated.
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