Synthetic microRNAs can control infection [Microbiology]

Systematic genetic perturbation screening in human cells remains technically challenging. Typically, large libraries of chemically synthesized siRNA oligonucleotides are used, each designed to degrade a specific cellular mRNA via the RNA interference (RNAi) mechanism. Here, we report on data from three genome-wide siRNA screens, conducted to uncover host factors required...

Source: Proceedings of the National Academy of Sciences - March 25, 2014 Category: Science Authors: Franceschini, A., Meier, R., Casanova, A., Kreibich, S., Daga, N., Andritschke, D., Dilling, S., Ramo, P., Emmenlauer, M., Kaufmann, A., Conde–Alvarez, R., Low, S. H., Pelkmans, L., Helenius, A., Hardt, W.–D., Dehio, C., von Mering, C. Tags: Biological Sciences Source Type: research