Advances and challenges in understanding histone demethylase biology.

Advances and challenges in understanding histone demethylase biology.
Curr Opin Chem Biol. 2016 Jun 29;33:151-159
Authors: Nowak RP, Tumber A, Johansson C, Che KH, Brennan P, Owen D, Oppermann U
Abstract
Within the last decade we have witnessed significant progress in the field of chromatin methylation, ranging from the discovery that chromatin methylation is reversible, to the identification of two classes of oxidative chromatin demethylases. Multiple genetic and cellular studies emphasize the role of members of the amine oxidase and 2-oxoglutarate oxygenase enzyme families involved in methyl-lysine in physiology and disease. Advances in understanding of the underlying biochemistry have resulted in development of first series of clinical inhibitors and tool compounds which continue to resolve and help understand the complex relationships between chromatin modification, control of gene expression and metabolic states.
PMID: 27371875 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - June 28, 2016 Category: Biochemistry Authors: Nowak RP, Tumber A, Johansson C, Che KH, Brennan P, Owen D, Oppermann U Tags: Curr Opin Chem Biol Source Type: research