p21 shapes cancer evolution
Nature Cell Biology 18, 722 (2016).
doi:10.1038/ncb3382
Authors: Vasily S. Romanov & K. Lenhard Rudolph
Although known to induce cellular senescence, an important tumour suppressor mechanism, mutation of CDKN1A — the gene encoding p21 (also known as WAF1 or CIP1) — is rare in human cancers. Now, a study reports a previously unappreciated oncogenic effect of p21 overexpression that shapes cancer genome evolution through induction of replication stress.
Source: Nature Cell Biology - Category: Cytology Authors: Vasily S. RomanovK. Lenhard Rudolph Tags: News and Views Source Type: research