Reliable Detection of Mismatch Repair Deficiency in Colorectal Cancers Using Mutational Load in Next-Generation Sequencing Panels [Gastrointestinal Cancer]

Conclusion
A cutoff for mutational load can be identified via multigene NGS tumor profiling, which provides a highly accurate means of screening for MMR-D in the same assay that is used for tumor genotyping.

Source: Journal of Clinical Oncology - June 7, 2016 Category: Cancer & Oncology Authors: Stadler, Battaglin, Middha, Hechtman, Tran, Cercek, Yaeger, Segal, Varghese, Reidy-Lagunes, Kemeny, Salo-Mullen, Ashraf, Weiser, Garcia-Aguilar, Robson, Offit, Arcila, Berger, Shia, Solit, Saltz Tags: ASCO Guidelines, Diagnosis & Staging, Translational Oncology, Gastrointestinal, Gene Expression and Profiling, Oncogenes Gastrointestinal Cancer Source Type: research