Clinical and Genetic Risk Factors for Acute Pancreatitis in Patients With Acute Lymphoblastic Leukemia [Hematologic Malignancy]

Conclusion
Older age, higher exposure to asparaginase, and higher Native American ancestry were independent risk factors for pancreatitis in patients with acute lymphoblastic leukemia. Those who inherit a nonsense rare variant in the CPA2 gene had a markedly increased risk of asparaginase-induced pancreatitis.

Source: Journal of Clinical Oncology - June 7, 2016 Category: Cancer & Oncology Authors: Liu, Yang, Devidas, Cheng, Pei, Smith, Carroll, Raetz, Bowman, Larsen, Maloney, Martin, Mattano, Winick, Mardis, Fulton, Bhojwani, Howard, Jeha, Pui, Hunger, Evans, Loh, Relling Tags: Acute Lymphoblastic Leukemia Hematologic Malignancy Source Type: research