Mitochondrial therapy improves limb perfusion and myopathy following hindlimb ischemia

Critical limb ischemia is a devastating manifestation of peripheral arterial disease with no effective strategies for improving morbidity and mortality outcomes. We tested the hypothesis that cellular mitochondrial function is a key component of limb pathology and that improving mitochondrial function represents a novel paradigm for therapy. BALB/c mice were treated with a therapeutic mitochondrial-targeting peptide (MTP-131) and subjected to limb ischemia (HLI). Compared to vehicle control, MTP-131 rescued limb muscle capillary density and blood flow (64.7±11% of contralateral vs.

Source: Journal of Molecular and Cellular Cardiology - May 31, 2016 Category: Cytology Authors: Terence E. Ryan, Cameron A. Schmidt, Rick J. Alleman, Alvin M. Tsang, Thomas D. Green, P. Darrell Neufer, David A. Brown, Joseph M. McClung Tags: Short communication Source Type: research