Effects of Hindlimb Unweighting on MBP and GDNF Expression and Morphology in Rat Dorsal Root Ganglia Neurons.

In conclusion, HU treatment induced damage of L5 DRG neurons, which was correlated with decreased total MBP protein expression, increased dgen-MBP expression, and reduced GDNF protein and mRNA expression. Importantly, these changes were more severe in F-HU rats compared with M-HU rats.
PMID: 27230884 [PubMed - as supplied by publisher]

Source: Neurochemical Research - May 25, 2016 Category: Neuroscience Authors: Zhang H, Ren NT, Zhou FQ, Li J, Lei W, Liu N, Bi L, Wu ZX, Zhang R, Zhang YG, Cui G Tags: Neurochem Res Source Type: research