Baclofen-induced neurotoxicity in a patient with end-stage renal disease.

Baclofen-induced neurotoxicity in a patient with end-stage renal disease. Saudi J Kidney Dis Transpl. 2016 May-Jun;27(3):595-597 Authors: Radhakrishnan H Abstract Baclofen, predominantly excreted by the kidneys is accumulated in patients with renal insufficiency leading to the central nervous system toxicity. Here the author reports a patient with end-stage renal disease on maintenance hemodialysis (HD) who developed drowsiness and became unresponsive within a day after taking single 10 mg dose of baclofen. Patient improved completely after two sessions of HD. PMID: 27215257 [PubMed - as supplied by publisher]
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research