Pharmacokinetics and excretion of 14 C-omacetaxine in patients with advanced solid tumors

Conclusion Renal and hepatic processes contribute to the elimination of 14C-omacetaxine-derived radioactivity in cancer patients. In addition to omacetaxine and its known metabolites, other 14C-omacetaxine-derived materials appear to be present in plasma and urine. Omacetaxine was adequately tolerated, with no new safety signals.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research