Abstract A37: Tumor heterogeneity in SCLC: A role for endogenous Notch signaling

In conclusion, Notch is a potent suppressor of SCLC. However, Notch may have pro-tumorigenic effects in SCLC, possibly under stress conditions. A better understanding of the molecular and cellular roles of Notch is required before therapeutic strategies manipulating the Notch pathway can be used in SCLC patients.Citation Format: Jing Shan Lim, Alvaro Ibaseta, Dian Yang, Nadine S. Jahchan, Julien Sage. Tumor heterogeneity in SCLC: A role for endogenous Notch signaling. [abstract]. In: Proceedings of the AACR Special Conference: Developmental Biology and Cancer; Nov 30-Dec 3, 2015; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Res 2016;14(4_Suppl):Abstract nr A37.

Source: Molecular Cancer Research - May 2, 2016 Category: Cancer & Oncology Authors: Lim, J. S., Ibaseta, A., Yang, D., Jahchan, N. S., Sage, J. Tags: Signaling Pathways: Notch: Poster Presentations - Proffered Abstracts Source Type: research