Monthly News Roundup - April 2016

First-Time Generic Approved for Statin Crestor High cholesterol, high low-density lipoprotein (LDL) or “bad cholesterol”, and triglycerides increase the risk for serious heart disease and may lead to heart attacks and strokes. The FDA has now...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news

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Conclusions: The primary prevention of cardiovascular disease via a reduction in dietary salt consumption appeared much more effective than secondary or tertiary prevention approaches. Our simple but comprehensive model offers a potentially attractive methodological approach that might now be extended and replicated in other contexts and populations. PMID: 30838048 [PubMed - in process]
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research
ConclusionsIn the oldest old ( ≥ 80 years), statin users were fewer and had more often an established indication, suggesting that physicians extrapolate scientific evidence for beneficial effects in younger age groups to the oldest, but require a more solid ground for treatment. As the oldest old, nursing home residents, and those with multi-dose drug-dispensing were statin users to a lesser extent, physicians may often refrain from treatment in those with lower life expectancy, either due to age or to severely reduced health status. In both age groups, our results however also indicate some over- as well as undertreat ment.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
Offering statins to all over-75s could prevent 8,000 deaths from heart failure and stroke, researchers sayThousands of deaths and the wrecking of many lives by disability could be averted if doctors routinely offered a daily statin pill to older people, scientists say.They blame misinformation about the side-effects of statins, together with society ’s ageism, for the low uptake among older people, who are at highest risk of heart attacks, heart failure and stroke.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Statins Heart attack Heart disease Stroke Older people Health Medical research Society Science UK news Source Type: news
AbstractBromodomain and extra-terminal (BET) inhibitors, acting via epigenetic mechanisms, have been developed recently as potential new treatments for cancer, including prostate cancer, and inflammatory conditions. Some BET inhibitors, such as RVX-208, also raise high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-1 levels. A recent meta-analysis of three small trials (n = 798) found that RVX-208 protected against major adverse cardiovascular events (MACE), raising the question as to whether this protective effect was an artefact, a chance finding, or mediated by HDL-C, anti-inflammatory pathwa...
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
In this issue of Metabolism, Ong et al [1] report that fibroblast growth factor 21 (FGF21) levels could predict major cardiovascular (CV) events (MCVE) in statin-treated patients with stable coronary heart disease (CHD) using data from the Treating to New Targets (TNT) trial (n  = 10,001; median follow-up = 4.9 years) [2]; MCVE were defined as a composite of CHD death, cardiac arrest, fatal or non-fatal stroke and non-fatal myocardial infarction (MI). In the Ong et al study [1], 1996 patients with plasma FGF21 concentrations available at baseline were analyzed; 1 835 of them had also FGF21 measurements at the 1-year timepoint.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research
People who live in neighborhoods with more green spaces may have less stress, healthier blood vessels and a lower risk of heart attacks and strokes.Residential greenness is associated with lower levels of sympathetic activation, reduced oxidative stress, and higher angiogenic capacity. This is independent of age, sex, race, smoking status, neighborhood deprivation, statin use, and roadway exposure.For this study (see the link below), researchers tested for a variety of biomarkers of stress and heart disease risk in blood and urine samples from 408 patients at a cardiology clinic in Louisville, Kentucky, USA.Residents of th...
Source: Clinical Cases and Images - Blog - Category: Universities & Medical Training Tags: Longevity Nature Source Type: blogs
Conclusion: The price of alirocumab would have to be reduced considerably to be cost-effective. Because substantial reductions already have occurred, we believe that timely, independent cost-effectiveness analyses can inform clinical and policy discussions of new drugs as they enter the market. Primary Funding Source: University of California, San Francisco, and Institute for Clinical and Economic Review. PMID: 30597485 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
(Natural News) Big Pharma’s “sweetheart products,” statin medications, are a class of synthetic compounds made in laboratories that allegedly lower cholesterol levels in order to help prevent strokes and heart attacks. Many statins contain a compound from red yeast rice called monacolin K, but make no mistake, all statins contain chemicals that cause a long list...
Source: - Category: Consumer Health News Source Type: news
(CHICAGO) — Taking fish oil or vitamin D? Big studies give long-awaited answers on who does and does not benefit from these popular nutrients. Fish oil taken by healthy people, at a dose found in many supplements, showed no clear ability to lower heart or cancer risks. Same for vitamin D. But higher amounts of a purified, prescription fish oil slashed heart problems and heart-related deaths among people with high triglycerides, a type of fat in the blood, and other risks for heart disease. Doctors cheered the results and said they could suggest a new treatment option for hundreds of thousands of patients like these. ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime Supplements Source Type: news
Omega-3 fatty acids, abundant in fish oil, are known to be good for the heart. Studies have shown that people who eat more fish rich in these fats have lower rates of heart problems and less risk of dying from heart disease compared to those who eat less. Those data have fueled a booming business in over-the-counter fish oil supplements. In a new study published in the New England Journal of Medicine, and presented at the American Heart Association annual meeting, researchers report that a highly purified version of omega-3 fats, called icosapent ethyl, can lower the risk of a number of heart-related events, including hear...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Heart Disease omega-3 Source Type: news
More News: Cardiology | Cholesterol | Crestor | Heart | Heart Disease | Pharmaceuticals | Rosuvastatin | Statin Therapy | Stroke