Controlling Global Transcriptome Output with MYC, Supercoils, and Topoisomerase

NCI’s Center for Cancer Research (CCR) Grand Rounds Dr. Levens received his M.D. and Ph.D. from the University of Chicago. Subsequently, he completed residency training in anatomic pathology at the Laboratory of Pathology, NCI, where he is now the chief of the Gene Regulation Section. Dr. Levens studies fundamental mechanisms of gene regulation, emphasizing the control of MYC function and expression. He and his team showed that MYC amplifies is a universal amplifier of gene expression. This explains much of MYC physiology and pathology, but also defines the need to control MYC levels precisely in real time. The Levens Lab has shown that torque generated during transcription of MYC modifies DNA structure dynamically at the FUSE element,that together with FUSE Binding Protein and FBP Interacting Repressor is molecular cruise control for MYC. Most recently he is exploring the genome-wide utilization of supercoiled driven changes in DNA to regulate genes in health and disease.Air date: 4/22/2016 12:00:00 PM
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