Exenatide exerts direct protective effects on endothelial cells through AMPK/Akt/eNOS pathway in a GLP-1 receptor dependent manner.

In conclusion, exenatide significantly improves coronary endothelial function in patients with newly-diagnosed type 2 diabetes. The effect may be mediated through activation of AMPK/PI3K-Akt/eNOS pathway via a GLP-1R/cAMP-dependent mechanism. PMID: 27072494 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/27072494?dopt=Abstract

Source: Am J Physiol Endocri... - April 11, 2016 Category: Endocrinology Authors: Wei R, Ma S, Wang C, Ke J, Yang J, Li W, Liu Y, Hou W, Feng X, Wang G, Hong T Tags: Am J Physiol Endocrinol Metab Source Type: research