Kinase analysis in alcoholic hepatitis identifies p90RSK as a potential mediator of liver fibrogenesis

Conclusions
p90RSK is upregulated in patients with chronic liver disease and mediates liver fibrogenesis in vivo and in vitro. These results suggest that the p90RSK pathway could be a new therapeutic approach for liver diseases characterised by advanced fibrosis.

Source: Gut - April 7, 2016 Category: Gastroenterology Authors: Morales-Ibanez, O., Affo, S., Rodrigo-Torres, D., Blaya, D., Millan, C., Coll, M., Perea, L., Odena, G., Knorpp, T., Templin, M. F., Moreno, M., Altamirano, J., Miquel, R., Arroyo, V., Gines, P., Caballeria, J., Sancho-Bru, P., Bataller, R. Tags: Cirrhosis, Hepatitis other Hepatology Source Type: research