Neuropathy Associated HSPB1 Mutations Result in Loss of Neuroprotection in an In Vitro Model of Astrocyte Toxicity to Motor Neurons (P5.021)

Conclusions:Expression of HSPB1 in astrocytes influences motor neuron viability. Our results suggest that the expression of HSPB1 mutations that are associated with an axonal hereditary neuropathy have the potential to exert deleterious effects on motor neurons in a non-cell autonomous manner.Disclosure: Dr. Heilman has nothing to disclose. Dr. Song has nothing to disclose. Dr. Miranda has nothing to disclose. Dr. Meyer has nothing to disclose. Dr. Best has nothing to disclose. Dr. Kaspar has nothing to disclose. Dr. Kolb has nothing to disclose.

Source: Neurology - April 3, 2016 Category: Neurology Authors: Heilman, P., Song, S., Miranda, C., Meyer, K., Best, C., Kaspar, B., Kolb, S. Tags: Genetics of Peripheral Neuropathies Source Type: research