Hu Antigen R Is a Positive Regulator of ALS-Associated RNA Binding Proteins TDP-43 and FUS (P5.008)

Conclusions: 1. ALS-associated RNA abnormalities may stem from disruption of a network of RBPs. 2. HuR positively regulates TDP-43 and FUS through posttranscriptional mechanism. 3. Loss of HuR-mediated RNA processing in astrocytes may participate in ALS pathogenesis. Study supported by: Study supported by NIH/NINDS Grant NS057664, NS064133Disclosure: Dr. Lu has nothing to disclose. Dr. Zheng has nothing to disclose. Dr. Si has nothing to disclose. Dr. King has nothing to disclose.

http://www.neurology.org/cgi/content/short/86/16_Supplement/P5.008?rss=1

Source: Neurology - April 3, 2016 Category: Neurology Authors: Lu, L., Zheng, L., Si, Y., King, P. Tags: Neuromuscular and Clinical Neurophysiology Poster Discussion Session Source Type: research