Abstract B07: Treatment of a chemoresistant human neuroblastoma cell-line (BE-2c) with experimental ozonide antimalarials

Conclusion: The antimalarial agent OZ513 has promising activity against the chemoresistant neuroblastoma cell-line BE-2c by increasing apoptosis by mechanisms that remain unclear, but increased cell cycle aneuploidy with treatment of cells with 5 mcg/ml of OZ513 indicates defects in mitosis and cytokinesis.Citation Format: Don W. Coulter, Timothy R. McGuire, John G. Sharp, Yuxiang Dong, Xiaofang Wang, Erin McIntyre, Xiaoyu Chen, Jon Vennerstrom. Treatment of a chemoresistant human neuroblastoma cell-line (BE-2c) with experimental ozonide antimalarials. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Pediatric Cancer Research: From Mechanisms and Models to Treatment and Survivorship; 2015 Nov 9-12; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(5 Suppl):Abstract nr B07.

Source: Cancer Research - April 3, 2016 Category: Cancer & Oncology Authors: Coulter, D. W., McGuire, T. R., Sharp, J. G., Dong, Y., Wang, X., McIntyre, E., Chen, X., Vennerstrom, J. Tags: Targeted Therapeutics and Resistance Source Type: research