Challenges and opportunities for siRNA-based cancer treatment

• Distinct rules for chemical modification of siRNA and antisense oligonucleotide• Optimised research model leads to predictable bio-distribution pattern of siRNAs• Characterisation of endosomal escape aids future siRNA-based cancer treatment• Gene target selection - cancer stem cell critical genes and multiple gene targeting• Aappropriate research controls and 5'RACE assay ensure minimum off-target effect

Source: Cancer Letters - March 31, 2016 Category: Cancer & Oncology Authors: Tao Wang, Sarah Shigdar, Hadi AlShamaileh, Michael P. Gantier, Wang Yin, Dongxi Xiang, Lan Wang, Shu-Feng Zhou, Yingchun Hou, Peng Wang, Weihong Zhang, Chunwen Pu, Wei Duan Tags: Mini-review Source Type: research