Long Non-coding RNAs and the Homeostasis of Innate Immune Cells

Immunology Interest Group Jorge Henao-Mejia obtained his M.D. in 2005 from the University of Antioquia, Medellin, Colombia and his Ph.D. in 2009 from Indiana University, Indianapolis. He was a post-doctoral fellow with Richard Flavell at Yale University, where he studied the interactions between the immune system and metabolism in the context of health and obesity. Since summer 2014, he has been on the Faculty at the University of Pennsylvania. His current research aims to understand the role of the innate immune system in the development of metabolic syndrome, and to comprehend the metabolic pathways that are necessary for appropriate immune responses. Jorge's laboratory has been pioneering novel mouse genetic tools to define the molecular mechanism of chronic inflammatory disorders, with a particular focus on long non-coding RNAs (see Cold Spring Harb Protoc 2016; doi:10.1101/pdb.prot090704), which he will discuss during his presentation. He is a rising star in the field and his talk is one not to miss. Abstract: Epigenetic modifications induced by extracellular cues enable cells to rapidly adapt to changes in their environment. Long non-coding RNAs (lncRNAs) are now considered key controllers of epigenetically regulated gene expression. Notably, emerging evidence indicates that lncRNAs play a critical role in integrating extracellular inputs with epigenetic modification pathways to promote changes in gene expression programs. Given the tight regulation that is required t...
Source: Videocast - All Events - Category: Journals (General) Tags: Upcoming Events Source Type: video

Related Links:

Conclusions: Patients with lymphedema and obesity should be viewed at high risk of developing recurrence of erysipelas and thus should be considered as candidates for antibiotic prophylaxis and other prevention methods. Minor local trauma directly preceding the skin infection does not by itself confer a higher risk for erysipelas recurrence. More research is needed to assess the association of recurrent skin and soft-tissue infection to preceding minor local trauma, individual components of the metabolic syndrome, and COPD. PMID: 32454817 [PubMed]
Source: Interdisciplinary Perspectives on Infectious Diseases - Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research
We, previously, demonstrated that children with Down syndrome (DS) exhibited a greater risk of steatosis than the general pediatric population. This trend is independent of obese phenotype, thus suggesting a role of genetic predisposition. Therefore, we investigated the prevalence of non-alcoholic fatty liver disease and metabolic syndrome (MetS) in function of genetic susceptibility and adipocytokine levels in children with DS.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Metabolic syndrome (MetS) is a condition characterized by the co-occurrence of metabolic risk factors for both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) [1,2]. It includes various combinations of abdominal obesity, elevated fasting plasma glucose (FPG), atherogenic dyslipidemia with elevated triglyceride levels, low high-density lipoprotein (HDL) cholesterol levels, and elevated blood pressure (BP) [3]. The modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) definition is one of the most widely used criteria for MetS [4], because it uses available clinical variabl...
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
The Hawaii –Los Angeles–Hiroshima Study: the medical survey of Japanese Americans for 50 years. AbstractA medical survey of Japanese Americans have been carried out since 1970; in particular, this survey was administered to the Japanese emigrants from Hiroshima (Japan) to Hawaii or Los Angeles (USA) and their offspring. Labeled the Hawaii –Los Angeles–Hiroshima Study, it constituted a long‐term epidemiological study of Japanese Americans who are genetically identical to the native Japanese people, but have experienced rapid and intense Westernization in terms of their lifestyles. The authors ...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Mini Review Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
In conclusion, GL extract shows antiobesity effects in vitro and in vivo, suggesting that this extract can be beneficial in the prevention of obesity.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
More News: Allergy & Immunology | Eating Disorders & Weight Management | Environmental Health | General Medicine | Genetics | Health | Laboratory Medicine | Metabolic Syndrome | Obesity | University of Pennsylvania | Yale