Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.

Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.
Am J Pathol. 2016 Mar 15;
Authors: Murakami R, Matsumura N, Mandai M, Yoshihara K, Tanabe H, Nakai H, Yamanoi K, Abiko K, Yoshioka Y, Hamanishi J, Yamaguchi K, Baba T, Koshiyama M, Enomoto T, Okamoto A, Murphy SK, Mori S, Mikami Y, Minamiguchi S, Konishi I
Abstract
Recently, The Cancer Genome Atlas data revealed four molecular subtypes of high-grade serous ovarian cancer (HGSOC) that exhibited distinct prognoses on the basis of a transcriptome analysis. We developed a novel histopathological classification dividing HGSOC into four subtypes: mesenchymal transition, defined by remarkable desmoplastic reaction, immune reactive by lymphocytes surrounding and infiltrating tumor, solid and proliferative by a solid growth pattern, and papilloglandular by a papillary architecture. Unsupervised hierarchical clustering revealed four clusters correlated with histopathological subtypes in both Kyoto and Niigata HGSOC gene expression microarray data sets (P < 0.001). Gene set enrichment analysis revealed pathways enriched in our histopathological classification significantly overlapped with the four Cancer Genome Atlas molecular subtypes: mesenchymal, immunoreactive, proliferative, and differentiated (P < 0.0001, respectively). In 132 HGSOC cases, progression-free survival and...

Source: The American Journal of Pathology - March 15, 2016 Category: Pathology Authors: Murakami R, Matsumura N, Mandai M, Yoshihara K, Tanabe H, Nakai H, Yamanoi K, Abiko K, Yoshioka Y, Hamanishi J, Yamaguchi K, Baba T, Koshiyama M, Enomoto T, Okamoto A, Murphy SK, Mori S, Mikami Y, Minamiguchi S, Konishi I Tags: Am J Pathol Source Type: research