Retinal thickness measured with optical coherence tomography and risk of disability worsening in multiple sclerosis: a cohort study

Publication date: Available online 18 March 2016 Source:The Lancet Neurology Author(s): Elena H Martinez-Lapiscina, Sam Arnow, James A Wilson, Shiv Saidha, Jana Lizrova Preiningerova, Timm Oberwahrenbrock, Alexander U Brandt, Luis E Pablo, Simone Guerrieri, Ines Gonzalez, Olivier Outteryck, Ann-Kristin Mueller, Phillip Albrecht, Wesley Chan, Sebastian Lukas, Lisanne J Balk, Clare Fraser, Jette L Frederiksen, Jennifer Resto, Teresa Frohman, Christian Cordano, Irati Zubizarreta, Magi Andorra, Bernardo Sanchez-Dalmau, Albert Saiz, Robert Bermel, Alexander Klistorner, Axel Petzold, Sven Schippling, Fiona Costello, Orhan Aktas, Patrick Vermersch, Celia Oreja-Guevara, Giancarlo Comi, Letizia Leocani, Elena Garcia-Martin, Friedemann Paul, Eva Havrdova, Elliot Frohman, Laura J Balcer, Ari J Green, Peter A Calabresi, Pablo Villoslada Background Most patients with multiple sclerosis without previous optic neuritis have thinner retinal layers than healthy controls. We assessed the role of peripapillary retinal nerve fibre layer (pRNFL) thickness and macular volume in eyes with no history of optic neuritis as a biomarker of disability worsening in a cohort of patients with multiple sclerosis who had at least one eye without optic neuritis available. Methods In this multicentre, cohort study, we collected data about patients (age ≥16 years old) with clinically isolated syndrome, relapsing-remitti...
Source: The Lancet Neurology - Category: Neurology Source Type: research