Estradiol variability, stressful life events, and the emergence of depressive symptomatology during the menopausal transition

Conclusions: These data suggest that estradiol variability may enhance emotional sensitivity to psychosocial stress, particularly sensitivity to social rejection. Combined with VSLEs proximate to the menopausal transition, this increased sensitivity may contribute to the development of depressed mood.
Source: Menopause - Category: OBGYN Tags: Original Articles Source Type: research