Diagnosis, treatment and prognosis in patients with liver metastases from follicular thyroid carcinoma (FTC).

Diagnosis, treatment and prognosis in patients with liver metastases from follicular thyroid carcinoma (FTC).
Endokrynol Pol. 2016 Feb 17;
Authors: Kałużna M, Gołąb M, Czepczyński R, Dworacki G, Bręborowicz D, Orłowski M, Katulska K, Klimowicz A, Gryczyńska M, Ruchała M, Ziemnicka K
Abstract
Follicular thyroid carcinoma (FTC) is the second most common type of thyroid cancer (TC) and accounts for approximately 10 percent of all TC cases. Liver metastases are rare presentation in 0.5-1% of follicular thyroid cancers, usually occur in the setting of widely disseminated FTC disease and their presence is associated with poor prognosis. Until now, there are only 30 cases of FTC liver metastases described in the literature. Hereby, we review publications and describe diagnostic tools, which may be used in the diagnosis and follow-up of FTC metastases to the liver including biopsy, imaging techniques like US, CT, MRI, SPECT, PET and radioiodine scintigraphy. We also present and discuss current methods of treatment e.g. TSH suppressive therapy with levothyroxine, surgery, radiofrequency ablation (RFA), transarterial embolization (TAE), liver transarterial chemoembolization (TACE), chemotherapy with cisplatin and doxorubicin, treatment with Indium-111-octreotide (or its analogs) and tyrosine kinase inhibitors (sorafenib, sunitinib). At the end we describe course, results of diagnostics and treatment in patient with large multiple FTC ...

Source: Endokrynologia Polska - February 17, 2016 Category: Endocrinology Authors: Kałużna M, Gołąb M, Czepczyński R, Dworacki G, Bręborowicz D, Orłowski M, Katulska K, Klimowicz A, Gryczyńska M, Ruchała M, Ziemnicka K Tags: Endokrynol Pol Source Type: research