Direct evidence for activated CD8+ T cell transmigration across portal vein endothelial cells in liver graft rejection

Conclusions We show for the first time direct evidence of T-cell transmigration across PV endothelial cells during hepatic allograft rejection. Interactions between VCAM-1 on endothelia and α4β1 integrin on recipient effector T-cells putatively play critical roles in adhesion and transmigration through endothelia. A chemokine axis of CXCL10 and CXCR3 also may be involved.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research