Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges

Abstract The association between thyroid hormone status and plasma levels of low-density lipoprotein cholesterol has raised the awareness for the development of thyroid hormone mimetics as lipid-lowering agents. The discovery of the two main types of thyroid hormone receptors (α and β) as well as the development of novel combinatorial chemistry providing organ specificity has drastically improved the selectivity of these compounds. In the past decades, several thyroid hormone mimetics have been investigated with the purpose of lowering low-density lipoprotein cholesterol levels. However, until now, none of the thyromimetics reached the stage of completing a phase III clinical trial without deleterious side effects. Here, we review the currently available literature on thyromimetics investigated for the treatment of dyslipidemia, their rise, their downfall and the challenges for the development of novel agents.
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research

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This study proved the high potential of MOG-derived nanostructured transition metal oxides (TMOs) with multiple complex functions.Graphical abstract
Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
CONCLUSION: The diabetic trained rats demonstrate a protective effect of resistance training on the serum lipid profile. PMID: 31517608 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
CONCLUSION: Our findings showed that there is an association between rs17300539 with the increase of T2DM but rs266729 showed no association with the risk of T2DM. Allele A of rs17300539 increased the risk of diabetes. There is no association between adiponectin level and both polymorphisms. PMID: 31517610 [PubMed - in process]
Source: Endocrine Regulations - Category: Endocrinology Tags: Endocr Regul Source Type: research
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Contributors : R Maeso-Diaz ; J J Lozano ; J Gracia-SanchoSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusNASH is a severe form of NAFLD that can progress to cirrhosis and hepatocellular carcinoma and, its incidence has markedly increased in recent years. Current available animal models fail to reflect the whole spectrum of the disease. We herein designed a Barcelona NASH (BarNa) rat model using the combination of high fat&cholesterol diet with CCl4 inhalation for 10 weeks (NASH) or 24 weeks (NASH-CH). This model reflects the full spectrum of human NASH and present the main c...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research
ConclusionsCurrent study evidently demonstrates that the anti-hypercholesterolemic effects of HS are mediated through redox-sensitive modulation of inflammatory pathways.Graphical abstract
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
BEST supplements for cholesterol: High cholesterol is a dangerous precursor to a number of serious health complications. Taking steps to lower cholesterol can ward off the threat. A growing body of evidence supports taking natural supplements to keep the condition at bay. Here are three such supplements.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: October 2019Source: Biomedicine &Pharmacotherapy, Volume 118Author(s): Xinyu Ji, Shuai Shi, Bin Liu, Mingxu Shan, Danli Tang, Wantong Zhang, Yin Zhang, Lulu Zhang, Huamin Zhang, Cheng Lu, Yongyan WangAbstractDyslipidemia is a key risk factor for cardiovascular diseases, which are a major cause of morbidity and mortality worldwide. However, despite the advancement of the treatment and prevention of dyslipidemia, medications used to treat dyslipidemia are limited to chemical drugs. Herbal medicine, as an alternative treatment, has a long history of usage and provides more treatment options, and related ...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 September 2019Source: Journal of Cardiology CasesAuthor(s): Kota Motozato, Daisuke Sueta, Kenji Sakamoto, Suguru Nagamatsu, Takayoshi Yamashita, Ryota Sato, Tatsuro Mitsuse, Yusuke Kanemaru, Kyoji Takaoka, Koichiro Fujisue, Seiji Takashio, Yuichiro Arima, Eiichiro Yamamoto, Koichi Kaikita, Kenichi TsujitaAbstractThe low-density lipoprotein-cholesterol (LDL-C) level of a 60-year-old woman diagnosed with acute coronary syndrome (ACS) was 212 mg/dL. She was suspected of having familial hypercholesterolemia, therefore, administration of a proprotein convertase subtilisin-kexin type 9 ...
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Contributors : Lili Chen ; Valentina Strohmeier ; Zhengxiang He ; Madhura Deshpande ; Sergio A Lira ; Glaucia C FurtadoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe goal of this study is to check if elevated level of IL-23 and/or its downstream cytokines affect the gene expression in the jejunum of newborn mice. We engineered a mice strain in which the expression of IL-23 was directed to the keratinocytes (KSR23). The KSR23 mice had normal body weight at birth and much smaller than their control littermates at day 5. KSR23 mice died prematurely (before 15 days of age), but displ...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
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