Familial skin cancer syndromes

Nonmelanoma skin cancers (NMSCs) represent the most common malignancies worldwide, with reported incidence rising each year. Both cutaneous squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), as well as other NMSCs, represent complex diseases with a combination of environmental and genetic risk factors. In general, hereditary cancer syndromes that increase the risk of NMSC fall under several broad categories: those associated with immunodeficiencies, those that affect skin pigmentation, and those that perturb key molecular pathways involved in the pathogenesis of NMSCs.

http://www.jaad.org/article/S0190-9622(15)02365-8/abstract?rss=yes

Source: Journal of the American Academy of Dermatology - February 17, 2016 Category: Dermatology Authors: Prajakta D. Jaju, Katherine J. Ransohoff, Jean Y. Tang, Kavita Y. Sarin Tags: Continuing medical education Source Type: research