Prevalence and Clinical Characteristics of Headaches in PHACE Syndrome

The objective of this study was to characterize the clinical features and prevalence of headache by conducting a cross-sectional survey of families in 2 large PHACE registries. Sixty-six percent of eligible families completed the survey in which 62.7% of respondents reported headaches. Average age of headache onset was 48.8 months. Females were more likely to have headaches (68.6% vs 30.8%, P = .014). Families reported associated migrainous features including nausea (62.5%), vomiting (37.5%), photophobia (75%), and phonophobia (75%). Headaches occurred at least weekly in 29.4%, lasted ≥1 hour in 85.4%, and led to ≥1 hospital admission in 15.7%. Three respondents with headaches had at least 1 ischemic stroke. We demonstrated that headaches are common among PHACE patients, develop at an early age, and have migrainous features.

Source: Journal of Child Neurology - February 8, 2016 Category: Neurology Authors: Yu, J., Siegel, D. H., Drolet, B. A., Blei, F., Epstein, L. G., Metry, D., Heyer, G. L. Tags: Original Articles Source Type: research