Hyperglycemia Increases the Production of Amyloid Beta-Peptide Leading to Decreased Endothelial Tight Junction.

CONCLUSION: Hyperglycemia enhances APP expression with increased Aβ production, which downregulates junctional proteins causing increased intercellular permeability in ECs. PMID: 26842741 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26842741?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Chao AC, Lee TC, Juo SH, Yang DI Tags: CNS Neurosci Ther Source Type: research