Presymptomatic MPTP Mice Show Neurotrophic S100B/mRAGE Striatal Levels.

CONCLUSION: Our findings rule out the involvement of S100B/mRAGE axis in striatal reactive gliosis, DAergic axonopathy and warrant further exploration of its neurotrophic effects in a presymptomatic compensatory PD stage, which is a fundamental period for successful implementation of therapeutic strategies. PMID: 26843141 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26843141?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - February 4, 2016 Category: Neuroscience Authors: Viana SD, Fernandes RC, Canas PM, Silva AM, Carvalho F, Ali SF, Fontes Ribeiro CA, Pereira FC Tags: CNS Neurosci Ther Source Type: research