Risk-adapted approach to HLA-matched sibling hematopoietic cell allografting: impact of adjusting conditioning intensity and integrating post-transplant therapeutic interventions

Conclusion This risk-adapted combined approach of selecting conditioning intensity and integrating post-transplant therapies results in lower NRM and encouraging improvement in survival. Our findings warrant confirmation in a large prospective multicenter trial. Teaser Allo-HCT is a curative strategy for various hematologic malignancies. However, success is limited by mortality and relapse. We demonstrate the efficacy of a risk-adapted approach to HLA-matched sibling allo-HCT by adjusting intensity of busulfan according to age, disease risk and existing comorbidities, and by implementing appropriate post-transplant prophylactic maintenance therapy. Our findings require validation in a large multicenter study.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research