Nanotherapeutics for inhibition of atherogenesis and modulation of inflammation in atherosclerotic plaques

Conclusions
Sugar-based amphiphilic macromolecules can be complexed with α-T to establish new anti-athero-inflammatory nanotherapeutics. These dual efficacy NPs effectively inhibited key features of atherosclerosis (modified lipid uptake and the formation of foam cells) while demonstrating reduction in inflammatory markers based on a disease-mimetic model of human atherosclerotic plaques.

Source: Cardiovascular Research - January 25, 2016 Category: Cardiology Authors: Lewis, D. R., Petersen, L. K., York, A. W., Ahuja, S., Chae, H., Joseph, L. B., Rahimi, S., Uhrich, K. E., Haser, P. B., Moghe, P. V. Tags: Vascular Biology Source Type: research