p53 Mutation/Loss Enhances mTORC1 Activity

This study establishes that loss of p53 function decreases lysosomal TSC2 and increases lysosomal Rheb resulting in hyperactive mTORC1, findings that are consistent with a more malignant phenotype. Mol Cancer Res; 14(1); 66–77. ©2015 AACR.

Source: Molecular Cancer Research - January 15, 2016 Category: Cancer & Oncology Authors: Agarwal, S., Bell, C. M., Taylor, S. M., Moran, R. G. Tags: Oncogenes and Tumor Suppressors Source Type: research